| A Case of Primary hyperparathyroidism with concomitant Papillary Thyroid Carcinoma |
Sang Yoon Kim1, Eun Yeong Ha1
, Sun Young Kwon3, Jihyoung Cho4, Ho Chan Cho1
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1Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea
2Department of Internal Medicine, Alpha Alliance Internal Medicine Clinic, Daegu, Korea
3Department of Pathology, Keimyung University School of Medicine, Daegu, Korea
4Department of Surgery, Keimyung University School of Medicine, Daegu, Korea |
| Address for Correspondence: |
Ho Chan Cho ,Tel: 82-53-258-4920, Fax: 82-53-258-4920, Email: hochan3632@gmail.com
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Received: 6 January 2025; Accepted: 14 April 2025. Published online: 14 April 2025. |
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| ABSTRACT |
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Primary hyperparathyroidism (PHPT) with concomitant thyroid cancer is rare. PHPT is usually caused by a parathyroid adenoma and rarely by parathyroid carcinoma. Although an association between PHPT and well-differentiated thyroid carcinoma has been reported, it is often considered coincidental.
We report a case of a 50-year-old female presenting with tingling, shoulder pain, muscle weakness, and elevated serum calcium and parathyroid hormone levels. Neck ultrasonography revealed a hypoechoic mass in the left infrathyroidal region and thyroid nodules in both lobes. A Tc99m-MIBI parathyroid scan showed a focal hot nodule, and fine-needle aspiration confirmed papillary thyroid carcinoma, later verified by histopathology.
She underwent surgery and was diagnosed with PHPT and papillary thyroid carcinoma. This case highlights the importance of evaluating for concomitant thyroid malignancy in PHPT patients with suspicious thyroid nodules.
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| Keywords:
hyperparathyroidism, primary; thyroid cancer, papillary; hypercalcemia; thyroid nodule |
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